Humoral immune response of domestic dogs that received a single dose of rabies vaccine

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Viviane Alcântara da Silva
Thais Helena Martins Gamon
Andréa de Cássia Rodrigues da Silva
Graciane Maria Medeiros Caporale
Luciana Botelho Chaves
Karin Corrêa Scheffer

Abstract

The National Programme for Rabies Prevention aims to maintain
immunogenic protective levels in vaccinated animals, with titers
of neutralizing antibodies (VNA) ≥ 0.5 IU / mL. The aim of this
study was to evaluate, according to age, race, and the period
of vaccination and blood collection, the immune response in
dogs that received a single dose of rabies vaccine virus in cell
culture. In this study 432 samples received at the Pasteur Institute
of São Paulo in the triennium 2009-2011 were analyzed. Data
were analyzed and the evaluation of the VNA to rabies virus was
performed by rapid fluorescent inhibition test foci (RFFIT). Of the
total samples analyzed, 21.76% did not have protective titers.
Among these, 67.02% samples were considered puppies and
when the interval between the date of vaccine administration and
blood collection, 60.63% samples did not reach the titration in
the first six months. It was concluded from this study sample the
need for a second dose of vaccine in puppies, as they are more
susceptible to infection by rabies virus, which would increase the
possibility of a rapid and durable response.

Article Details

How to Cite
DA SILVA, V. A.; GAMON, T. H. M.; DA SILVA, A. DE C. R.; CAPORALE, G. M. M.; CHAVES, L. B.; SCHEFFER, K. C. Humoral immune response of domestic dogs that received a single dose of rabies vaccine. Revista de Educação Continuada em Medicina Veterinária e Zootecnia, v. 12, n. 1, p. 20–25, 24 Oct. 2014.
Section
PREVENTIVE VETERINARY MEDICINE