Continuous monitoring of interstitial glucose in healthy dogs

Abstract

The maintenance of body glucose in proper levels is of paramount
importance to the homeostasis control, offering a fundamental
energetic substrate for the proper organic performance. For the
purposes of measuring body glucose levels, there are available portable
and laboratory assessment techniques. Therefore, aiming at future
clinical trials on body glucose variation in dogs, it had the purpose of
observing the feasibility of a continuous interstitial glucose monitoring
system named CGMS® (Continuous Glucose Monitoring System,
Guardian Real-Time System/Medtronic/U.S.A.). Eight clinically healthy
dogs composed the study group and all of them presented the highest
interstitial glucose values during the contention and obtaining process
of venous blood samples for the device calibration and the lowest values
during the night period due to the lack of manipulation. It was also
performed the comparison of venous and interstitial glucose, evaluated
at the same moment and presenting a good agreement between
themselves. The median values of glucose obtained from venous
route were 82,5mg/dL; 81mg/dL; 80mg/dL; 78mg/dL; 86,5mg/dL;
83mg/dL; 84mg/dL; 99,5mg/dL whereas those.evaluated.by.CGMS®.
corresponded.to 77mg/dL; 77mg/dL; 69mg/dL; 80mg/dL; 81,5mg/dL;
76mg/dL; 52,5mg/dL; e 86mg/dL. There has been certain situations of
non-recording of data by removal of the sensor and light inflammatory
cutaneous reaction on the fixation site. Results obtained confirmed the
efficacy of CGMS® on the assessment of interstitial glucose within
the home settings and assisted, moreover also evidencing the need of
training to the device owner regarding its related handling.