Potential uses of the animal model Zebrafish Danio rerio in Veterinary Medicine researches

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Hirla Fukushima
R. L. BAILONE
I. BAUMGARTNER
R. C. BORRA
T. CORREA
L. K. DE AGUIAR
H. JANKE
R. ROÇA
P. G. SETTI

Abstract

Zebrafish (Danio rerio) is an excellent model body to evaluate the safety and efficacy of new chemicals in animal health in a fast and economical way. Considering that more than 1,000 new chemicals are marketed annually for the development of products such as vaccines, drugs, food additives and agrochemicals, the purpose of this review is to present the Zebrafish as a model for assessing the efficacy and biotoxicity of compounds in the veterinary scope. Numerous studies have confirmed that profiles between Zebrafish and mammals are surprisingly similar, and their transparency, external fertilization, small size and short life cycle allow direct in vivo and real-time evaluation of (i) effects of chemical compounds in the development of animals, (II) efficacy of new drugs in the treatment of specific diseases, (iii) efficacy and safety in the development of vaccines against infectious diseases, (iv) directing the treatment of animal cancer in a more targeted and specific way. Therefore, the practicality and efficiency of its use in research can accelerate the process of developing new veterinary and agricultural compounds with less expenses when compared to tests carried out in other animal models and with higher predictive and informative value than in vitro tests.

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How to Cite
FUKUSHIMA, H.; BAILONE, R. L.; BAUMGARTNER, I.; BORRA, R. C.; CORREA, T.; DE AGUIAR, L. K.; JANKE, H.; ROÇA, R.; SETTI, P. G. Potential uses of the animal model Zebrafish Danio rerio in Veterinary Medicine researches. Revista de Educação Continuada em Medicina Veterinária e Zootecnia, v. 18, n. 1, 1 Jun. 2020.
Section
PREVENTIVE VETERINARY MEDICINE