Etilephrine effects on the cardiorespiratory function ofdogs anesthetized by thiopental and halothane, pretreated or not with methotrimeprazine
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Abstract
A long duration sympathomimetic agent, alfa-I, beta-l and beta-2 agonist, etilephrine was studied in 40 dogs, males and females, divided into four groups. The cardiorespiratory function was evaluated under thiopental and halothane anesthesia, with or without etilephrine administration and with or without methotrirneprazine pretreatment. It was found that heart rate (HR), systolic blood pressure (SBP), average blood pressure (ABP), diastolic blood pressure (DBP) and central venous pressure (CVP) were significantly increased (p<O.OS) in the group that was not pretreated with methotrimeprazine but received etilephrine (Group II) when compared to their control (Group I). On the other hand, the group of animals pretreated with methotrimeprazine that also received etilephrine (Group IV) displayed increased heart rate but SBP, ABP, DBP and CVP were considerably reduced when compared to their control (Group li). Regarding its arrhythmogenic effect, it was observed that some animals in Group II had ventricular extrasystole after treatment with etilephrine. This was not observed in Group IV. Besides the hemodynamic properties, some analeptic action was detected through the minute volume increase, although it was not significant (p<O.OS).
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